WHO Collaborating Centre for Drug Statistics Methodology
Norwegian Institute of Public Health
P.O.Box 4404 Nydalen
0403 Oslo
Norway
Visiting address:
Marcus Thranes gate 6,
0473 Oslo, Norway
Tel: + 47 21 07 81 60
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DDD alterations from 1982-2010

Cumulative overview of all DDD alterations performed in the period 1982-2010. The year changed is when the alterations were implemented in the ATC/DDD Index. Please note that a DDD may have changed more than once for some ATC codes. The ATC codes are current codes. For substances where the DDD is changed twice the new DDD which is not according to current value is marked with an asterix (*).

List of abbrevations

Substance	Previous DDD			New DDD*			Present ATC code	Year changed

Acebutolol	0.6	g	O,P	0.4	g	O,P	C07AB04	1987
Aciclovir	1	g	O,P	4	g	O,P ¹⁾	J05AB01	1995
Alosetron	2	mg	O	1	mg	O	A03AE01	2005
Amoxicillin and enzyme inhibitor	1	g	P	3	g	P	J01CR02	2005
Amprenavir	2.4	g	O	1.2	g	O	J05AE05	2006
Amrinone	0.15	g	P	0.5	g	P	C01CE01	1991
Atenolol	0.1	g	O,P	75	g	O,P	C07AB03	1995
Atorvastatin	10	mg	O	20	mg	O	C10AA05	2009
Azlocillin	6	g	P	12	g	P	J01CA09	1991
Beclomethasone inhal aer/powd.	0.4	mg		0.8	mg		R03BA01	1991
Benazepril	20	mg	O	7.5	mg	O	C09AA07	1995
Benzylpenicillin	2	MU	P	3.6	MU	P ²⁾	J01CE01	1991
Bezitramide	10	mg	O	15	mg	O	N02AC05	2004
Budesonide	0.3	mg	N	0.2	mg	N	R01AD05	2003
Budesonide inhal. aer/powd.	0.3	mg		0.8	mg		R03BA02	1991
Cabergoline	1	mg	O	0.5	mg	O	G02CB03	1997
Cabergoline	4	mg	O	3	mg	O	N04BC06	2001
Captopril	0.15	g	O	50	g	O	C09AA01	1989
Carbocisteine	1	g	O	1.5	g	O	R05CB03	1987
Carvedilol	50	mg	O	37.5	mg	O	C07AG02	1995
Cefaclor	2	g	O	1.5	g	O*	J01DC04	1992
Cefaclor	1.5	g	O	1	g	O	J01DC04	2000
Cefaloridine	2	g	P	3	g	P	J01DB02	1992
Cefamandole	2	g	P	6	g	P	J01DC03	1992
Cefatrizine	2	g	O	1	g	O	J01DB07	2000
Cefazolin	2	g	P	3	g	P	J01DB04	1992
Cefepime	4	g	P	2	g	P	J01DE01	2000
Cefoperazone	2	g	P	6	g	P*	J01DD12	1992
Cefoperazone	6	g	P	4	g	P	J01DD12	2000
Cefotaxime	2	g	P	6	g	P*	J01DD01	1992
Cefotaxime	6	g	P	4	g	P	J01DD01	2000
Cefotetan	2	g	P	4	g	P	J01DC05	1992
Cefotiam	2	g	P	4	g	P	J01DC07	1992
Cefoxitin	2	g	P	6	g	P	J01DC01	1992
Cefradine	3	g	O,P	2	g	O,P	J01DB09	1992
Cefsulodin	4	g	P	6	g	P*	J01DD03	1992
Cefsulodin	6	g	P	4	g	P	J01DD03	2000
Ceftazidime	4	g	P	6	g	P*	J01DD02	1992
Ceftazidime	6	g	P	4	g	P	J01DD02	2000
Ceftezole	6	g	P	3	g	P	J01DB12	2008
Ceftizoxime	2	g	P	4	g	P	J01DD07	1992
Cefuroxime	1	g	O	0.5	g	O	J01DC02	2000
Cefuroxime	4	g	P	3	g	P	J01DC02	2000
Cimetidine	1	g	O,P	0.8	g	O,P	A02BA01	1989
Ciprofloxacin	1	g	P	0.5	g	P	J01MA02	1992
Clobutinol	0.3	g	O,P	0.12	g	O,P	R05DB03	1987
Conjugated estrogens	1.25	mg	O	0.625	mg	O	G03CA57	1995
Cromoglicic acid inhal aersol	8	mg		40	mg		R03BC01	1991
Dalteparin	25	TU	P	3	TU	P*	B01AB04	1993
Dalteparin	3	TU	P	2.5	TU	P	B01AB04	2000
Danaparoid	25	TU	P	3	TU	P*	B01AB09	1993
Danaparoid	3	TU	P	1.5	TU	P	B01AB09	2000
Dapsone	0.125	g	O	50	g	O	J04BA02	1991
Desmopressin	0.36	mg ¹⁾	SL	0.24	mg ¹⁾	SL	H01BA02	2009
Dexibuprofen	1	g	O	0.8	g	O	M01AE14	2000
Dipyridamole	0.15	g	O	0.4	g	O	B01AC07	1991
Dipyridamole	0.15	g	P	0.2	g	P	B01AC07	1991
Doxazosin	8	mg	O	4	mg	O	C02CA04	1992
Enalapril	20	mg	O,P	10	mg	O,P	C09AA02	1995
Enoxaparin	25	TU	P	3	TU	P*	B01AB05	1993
Enoxaparin	3	TU	P	2.0	TU	P	B01AB05	2000
Epinephrine inhal. solution	22.5	mg		20	mg		R03AA01	1989
Erythromycin	1	g	O	2	g	O ³⁾	J01FA01	1990
Erythropoietin	2	TU	P	1	TU	P	B03XA01	2002
Esomeprazole	20	mg	O	30	mg	O	A02BC05	2005
Ethylmorphine	0.1	g	O	50	g	O	R05DA01	1987
Etidronic acid	1.4	g	O	0.4	g	O ⁴⁾	M05BA01	1999
Etilefrine	10	mg		50	mg		C01CA01	1985
Felodipine	15	mg	O	7.5	mg	O	C08CA02	1991
Felodipine	7.5	mg	O	5	mg	O*	C08CA02	1995
Fentanyl	0.6	mg	TD	1.2	mg	TD	N02AB03	2005
Flunitrazepam	2	mg		1	mg		N05CD03	1982
Fluticasone	0.3	mg	N	0.2	mg	N	R01AD08	2000
Fluvastatin	40	mg	O	60	mg	O	C10AA04	2009
Fluvoxamine	0.15	g	O	0.1	g	O	N06AB08	1996
Folic acid	0.3 ⁸⁾	mg	O	0.4	mg	O	B03BB01	2003
Folic acid	10 ⁹⁾	mg	O	deleted			B03BB01	2003
Foscarnet	13	g	P	6.5	g	P	J05AD01	1993
Fosfomycin	4	g	P	8	g	P	J01XX01	1992
Fosinopril	30	mg	O	15	mg	O	C09AA09	1995
Galantamine	24	mg	O	16	mg	O	N06DA04	2004
Glyceryl trinitrate	2.5	mg	O	5	mg	O	C01DA02	1987
Heparin	50	TU	P	10	TU	P ⁵⁾	B01AB01	1996
Hydrochlorothiazide and potassium	50	mg	O	25	mg	O	C03AB03	1996
Hydrochlorothiazide	50	mg	O	25	mg	O	C03AA03	1996
Hydromorphone	4	mg	O	20	mg	O	N02AA03	2004
Ibrandronic acid	5	mg	P	6	mg	P	M05BA06	2007
Ibuprofen	0.8	g	O,R	1.2	g	O,R	M01AE01	1987
Isoprenaline	60	mg	O,P	90	mg	O,P	C01CA02	1987
Isosorbide dinitrate	20	mg	O	60	mg	O	C01DA08	1987
Ketoconazole	0.6	g	O	0.2	g	O	J02AB02	1989
Latamoxef	2	g	P	6	g	P*	J01DD06	1992
Latamoxef	6	g	P	4	g	P	J01DD06	2000
Leflunomide	15	mg	O	20	mg	O	L04AA13	2004
Levetiracetam	2	g	O	1.5	g	O	N03AX14	2005
Levofloxacin	0.25	g	O,P	0.5	g	O,P	J01MA12	2004
Lisinopril	20	mg	O	10	mg	O	C09AA03	1995
Lovastatin	40	mg	O	30	mg	O*	C10AA02	1994
Lovastatin	30	mg	O	45	mg	O	C10AA02	2009
Meclozine	25	mg	O,R	50	mg	O,R	R06AE05	1987
Medroxyprogesterone	7	mg	P	1.67	mg	P ⁶⁾	G03AC06	1995
Metoprolol	0.2	g	O,P	0.15	g	O,P	C07AB02	1995
Morphine	30	mg	O	0.1	mg	O	N02AA01	1987
Nadroparin	25	TU	P	3	TU	P*	B01AB06	1993
Nadroparin	3	TU	P	2.85	TU	P	B01AB06	2000
Nicotinyl alcohol	0.3	g	O	0.9	g	O	C10AD05	1990
Nitroprusside	0.3	g	P	50	g	P	C02DD01	1987
Ofloxacin	0.3	g	O	0.4	g	O	J01MA01	1993
Ondansetron	24	mg	O,	16	mg	O,	A04AA01	1994
Oxycodone	30	mg	O	75	mg	O	N02AA05	2004
Parnaparin	25	TU	P	3	TU	P*	B01AB07	1993
Parnaparin	3	TU	P	3.2	TU	P	B01AB07	2000
Pentoxifylline	0.3	g	O	1	g	O	C04AD03	1992
Pipemidic acid	2	g	O	0.8	g	O	J01MB04	1993
Piperazine	2	g	O	3.5	g	O	P02CB01	1997
Pravastatin	20	mg	O	30	mg	O	C10AA03	2009
Proxyphylline	0.8	g	O,P,R	1.2	g	O,P,R	R03DA03	1987
Quinapril	20	mg	O	15	mg	O	C09AA06	1995
Ramipril	5	mg	O	2.5	mg	O	C09AA05	1995
Repaglinide	6	mg	O	4	mg	O	A10BX02	2004
Reviparin	25	TU	P	3	TU	P*	B01AB08	1993
Reviparin	3	TU	P	1.43	TU	P	B01AB08	2000
Risedronic acid	30	mg	O	5	mg	O	M05BA07	2002
Risperidone	6	mg	O	5	mg	O	N05AX08	1999
Risperidone	1.8	mg	P depot	2.7	mg	P depot	N05AX08	2010
Rofecoxib	12.5	mg	O	25	mg	O	M01AH02	2004
Sertraline	75	mg	O	50	mg	O	N06AB06	1996
Simvastatin	20	mg	O	15	mg	O*	C10AA01	1994
Simvastatin	15	mg	O	30	mg	O	C10AA01	2009
Sirolimus	6	mg	O	3	mg	O	L04AA10	2006
Sotalol	0.3	g	O,P	0.16	g	O,P	C07AA07	1995
Sulindac	0.2	g	O,P,R	0.4	g	O,P,R	M01AB02	1987
Sulpiride	0.1	g	O,P	0.8	g	O,P	N05AL01	1985
Sumatriptan	0.1	g	O	50	g	O	N02CC01	2001
Teicoplanin	0.2	g	P	0.4	g	P	J01XA02	1994
Terbutaline	10	mg	O,P	15	mg	O,P	R03CC03	1991
Tinzaparin	25	TU	P	3	TU	P*	B01AB10	1993
Tinzaparin	3	TU	P	3.5	TU	P	B01AB10	2000
Tioctic acid	50	mg	O,P	0.2	mg	O,P	A16AX01	1993
Tixocortol	0.4	mg	N	8	mg	N	R01AD07	1991
Topiramate	0.4	g	O	0.3	g	O ⁷⁾	N03AX11	1999
Triazolam	0.5	mg		0.25	mg		N05CD05	1987
Zidovudine	1.5	g	O	0.6	g	O,P ⁷⁾	J05AF01	1999
Zidovudine	1.0	g	P	0.6	g	O,P ⁷⁾	J05AF01	1999

1) The new DDD is based on treatment of varicella zoster infections
2) 3.6 g benzylpenicillin correspond to 6 ME
3) Only valid for erythromycin ethylsuccinate tablets
4) Based on treatment of osteoporosis
5) The new DDD is based on prophylactic of thrombosis
6) The new DDD is a result of the ATC alterations to G03AC06 for single dose packages 150 mg/ml, 1 ml in 1995 and is based on use as a contraceptive
7) Based on combination therapy
8) Prophylactic dose
9) Therapeutic dose. Parenteral therapeutic dose unchanged.
10) Base

Last updated: 2009-12-16