WHOCC
Postal address:
WHO Collaborating Centre for Drug Statistics Methodology
Norwegian Institute of Public Health
P.O.Box 4404 Nydalen
0403 Oslo
Norway

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Marcus Thranes gate 6
0473 Oslo
Norway

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DDD alterations from 1982-2017

Cumulative overview of all DDD alterations performed in the period 1982-2017. The year changed is when the alterations were implemented in the ATC/DDD Index. Please note that a DDD may have changed more than once for some ATC codes. The ATC codes are current codes. For substances where the DDD is changed twice the new DDD which is not according to current value is marked with an asterix (*).

List of abbrevations

SubstancePrevious DDDNew DDD*Present ATC codeYear changed
Cimetidine1gO,P0.8gO,PA02BA011989
Esomeprazole20mgO30mgOA02BC052005
Alosetron2mgO1mgOA03AE012005
Ondansetron24mgO,16mgO,A04AA011994
Gliclazide0.16gO60mgOA10BB092011
Repaglinide6mgO4mgOA10BX022004
Thioctic acid50mgO,P0.2mgO,PA16AX011993
thioctic acid0.2gO,P0.6gO,PA16AX012017
Heparin50TUP10TU5)B01AB01 1996
Dalteparin25TUP3TUP*B01AB041993
Dalteparin3TUP2.5TUPB01AB042000
Enoxaparin25TUP3TUP*B01AB051993
Enoxaparin3TUP2.0TUPB01AB052000
Nadroparin25TUP3TUP*B01AB061993
Nadroparin3TUP2.85TUPB01AB062000
Parnaparin25TUP3TUP*B01AB071993
Parnaparin3TUP3.2TUPB01AB072000
Reviparin25TUP3TUP*B01AB081993
Reviparin3TUP1.43TUPB01AB082000
Danaparoid25TUP3TUP*B01AB091993
Danaparoid3TUP1.5TUPB01AB092000
Tinzaparin25TUP3TUP*B01AB101993
Tinzaparin3TUP3.5TUPB01AB102000
Dipyridamole0.15gO0.4gOB01AC071991
Dipyridamole0.15gP0.2gPB01AC071991
dabigatran etexilate 0.22gO0.3gOB01AE072016
rivaroxaban10mgO20mgOB01AF012016
apixaban5mgO10mgOB01AF022016
Blood coagulation factors1deleted 11)B02BD2017
Nonacog alfa1000UP450UPB02BD092011
Folic acid0.3 8)mgO0.4mgOB03BB012003
Folic acid10 9)mgOdeletedB03BB012003
Erythropoietin2TUP1TUPB03XA012002
Etilefrine10mg50mgC01CA011985
Isoprenaline60mgO,P90mgO,PC01CA021987
Amrinone0.15gP0.5gPC01CE011991
Glyceryl trinitrate2.5mgO5mgOC01DA021987
Isosorbide dinitrate20mgO60mgOC01DA081987
Doxazosin8mgO4mgOC02CA041992
Nitroprusside0.3gP50mgPC02DD011987
Hydrochlorothiazide50mgO25mgOC03AA031996
Hydrochlorothiazide and potassium50mgO25mgOC03AB031996
Pentoxifylline0.3gO1gOC04AD031992
Sotalol0.3gO,P0.16gO,PC07AA071995
Metoprolol0.2gO,P0.15gO,PC07AB021995
Atenolol0.1gO,P75mgO,PC07AB031995
Acebutolol0.6gO,P0.4gO,PC07AB041987
Carvedilol50mgO37.5mgOC07AG021995
Felodipine15mgO7.5mgOC08CA021991
Felodipine7.5mgO5mgO*C08CA021995
Captopril0.15gO50mgOC09AA011989
Enalapril20mgO,P10mgO,PC09AA021995
Lisinopril20mgO10mgOC09AA031995
Ramipril5mgO2.5mgOC09AA051995
Quinapril20mgO15mgOC09AA061995
Benazepril20mgO7.5mgOC09AA071995
Fosinopril30mgO15mgOC09AA091995
Simvastatin20mgO15mgO*C10AA011994
Simvastatin15mgO30mgOC10AA012009
Lovastatin40mgO30mgO*C10AA021994
Lovastatin30mgO45mgOC10AA022009
Pravastatin20mgO30mgOC10AA032009
Fluvastatin40mgO60mgOC10AA042009
Atorvastatin10mgO20mgOC10AA052009
Nicotinyl alcohol0.3gO0.9gOC10AD051990
Cabergoline1mgO0.5mgOG02CB031997
Medroxyprogesterone7mgP1.67mg6)G03AC061995
Conjugated estrogens1.25mgO0.625mgOG03CA571995
human menopausal gonadotrophin30UP75UPG03GA022016
mifepristone0.6 gO0.2gOG03XB012017
Desmopressin0.36mg 10)SL0.24mg 10)SLH01BA022009
Azlocillin6gP12gPJ01CA091991
Benzylpenicillin2MUP3.6MU2)J01CE011991
ampicillin and enzyme inhibitor212)P612)PJ01CR012017
Amoxicillin and enzyme inhibitor1gP3gPJ01CR022005
Cefaloridine2gP3gPJ01DB021992
Cefazolin2gP3gPJ01DB041992
Cefatrizine2gO1gOJ01DB072000
Cefradine3gO,P2gO,PJ01DB091992
Ceftezole6gP3gPJ01DB122008
Cefoxitin2gP6gPJ01DC011992
Cefuroxime1gO0.5gOJ01DC022000
Cefuroxime4gP3gPJ01DC022000
Cefamandole2gP6gPJ01DC031992
Cefaclor2gO1.5gO*J01DC041992
Cefaclor1.5gO1gOJ01DC042000
Cefotetan2gP4gPJ01DC051992
Cefotiam2gP4gPJ01DC071992
Cefotaxime2gP6gP*J01DD011992
Cefotaxime6gP4gPJ01DD012000
Ceftazidime4gP6gP*J01DD021992
Ceftazidime6gP4gPJ01DD022000
Cefsulodin4gP6gP*J01DD031992
Cefsulodin6gP4gPJ01DD032000
Latamoxef2gP6gP*J01DD061992
Latamoxef6gP4gPJ01DD062000
Ceftizoxime2gP4gPJ01DD071992
Cefoperazone2gP6gP*J01DD121992
Cefoperazone6gP4gPJ01DD122000
Cefepime4gP2gPJ01DE012000
Erythromycin1gO2g3)J01FA011990
Ofloxacin0.3gO0.4gOJ01MA011993
Ciprofloxacin1gP0.5gPJ01MA021992
Levofloxacin0.25gO,P0.5gO,PJ01MA122004
Pipemidic acid2gO0.8gOJ01MB041993
Teicoplanin0.2gP0.4gPJ01XA021994
Fosfomycin4gP8gPJ01XX011992
Ketoconazole0.6gO0.2gOJ02AB021989
posaconazole0.8gO0.3gOJ02AC042017
Dapsone0.125gO50mgOJ04BA021991
Aciclovir1gO,P4gO,P 1)J05AB011995
Foscarnet13gP6.5gPJ05AD011993
Amprenavir2.4gO1.2gOJ05AE052006
Zidovudine1.5gO0.6gO,P 7)J05AF011999
Zidovudine1.0gP0.6gO,P 7)J05AF011999
Sirolimus6mgO3mgOL04AA102006
Leflunomide15mgO20mgOL04AA132004
Sulindac0.2gO,P,R0.4gO,P,RM01AB021987
Ibuprofen0.8gO,R1.2gO,RM01AE011987
Dexibuprofen1gO0.8gOM01AE142000
Rofecoxib12.5mgO25mgOM01AH022004
Etidronic acid1.4gO0.4g4)M05BA011999
Ibrandronic acid5mgP6mgPM05BA062007
Risedronic acid30mgO5mgOM05BA072002
Morphine30mgO0.1gON02AA011987
Hydromorphone4mgO20mgON02AA032004
Oxycodone30mgO75mgON02AA052004
Fentanyl0.6mgTD1.2mgTDN02AB032005
Bezitramide10mgO15mgON02AC052004
Sumatriptan0.1gO50mgON02CC012001
Topiramate0.4gO0.3g7)N03AX111999
Levetiracetam2gO1.5gON03AX142005
Cabergoline4mgO3mgON04BC062001
Sulpiride0.1gO,P0.8gO,PN05AL011985
Risperidone6mgO5mgON05AX081999
Risperidone1.8mgP depot2.7mgP depotN05AX082010
Flunitrazepam2mg1mgN05CD031982
Triazolam0.5mg0.25mgN05CD051987
Sertraline75mgO50mgON06AB061996
Fluvoxamine0.15gO0.1gON06AB081996
Galantamine24mgO16mgON06DA042004
Piperazine2gO3.5gOP02CB011997
Budesonide 0.3mgN0.2mgNR01AD052003
Tixocortol0.4mgN8mgNR01AD071991
Fluticasone0.3mgN0.2mgNR01AD082000
Epinephrine inhal. solution22.5mg20mgR03AA011989
Beclomethasone inhal aer/powd.0.4mg0.8mgR03BA011991
Budesonide inhal. aer/powd.0.3mg0.8mgR03BA021991
tiotropium bromide18mcg 13)Inhal.powder10mcg 13)Inhal.powderR03BB042017
Cromoglicic acid inhal aersol8mg40mgR03BC011991
Terbutaline10mgO,P15mgO,PR03CC031991
Proxyphylline0.8gO,P,R1.2gO,P,RR03DA031987
Carbocisteine1gO1.5gOR05CB031987
Ethylmorphine0.1gO50mgOR05DA011987
Clobutinol0.3gO,P0.12gO,PR05DB031987
Meclozine25mgO,R50mgO,RR06AE051987
calcium acetate2gO6gOV03AE072017
1) The new DDD is based on treatment of varicella zoster infections
2) 3.6 g benzylpenicillin correspond to 6 ME
3) Only valid for erythromycin ethylsuccinate tablets
4) Based on treatment of osteoporosis
5) The new DDD is based on prophylactic of thrombosis
6) The new DDD is a result of the ATC alterations to G03AC06 for single dose packages 150 mg/ml, 1 ml in 1995 and is based on use as a contraceptive
7) Based on combination therapy
8) Prophylactic dose
9) Therapeutic dose. Parenteral therapeutic dose unchanged.
10) Base
11) DDDs for the various blood coagulation factors in all ATC 5th level codes in B02BD are deleted. No new DDDs will be established in B02BD Blood coagulation factors.
12) Refers to ampicillin
13) The DDD for tiotropium bromide is unchanged but has been defined as the content of one inhalation capsule (18 mcg) as tiotropium. Since there are different inhalation capsules on the market containing different amounts of active substance, the DDD is now defined as the delivered dose, which is the same (10 mcg) as tiotropium for all products.

Last updated: 2017-03-23