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WHO Collaborating Centre for Drug Statistics Methodology
Norwegian Institute of Public Health
Postboks 222 Skøyen
0213 Oslo
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DDD alterations from 2005-2021

Cumulative overview of all DDD alterations performed in the period 2005-2021. The year changed is when the alterations were implemented in the ATC/DDD Index. Please note that a DDD may have changed more than once for some ATC codes. The ATC codes are current codes. For substances where the DDD is changed twice the new DDD which is not according to current value is marked with an asterix (*).

List of abbrevations

Substance	Previous DDD			New DDD*			Present ATC code	Year changed
calcium acetate	2	g	O	6	g	O	V03AE07	2017
tiotropium bromide	18	mcg ⁴⁾	Inhal. powder	10	mcg ⁴⁾	Inhal. powder	R03BB04	2017
risperidone	1.8	mg	P depot	2.7	mg	P depot	N05AX08	2010
levetiracetam	2	g	O	1.5	g	O	N03AX14	2005
fentanyl	0.6	mg	TD	1.2	mg	TD	N02AB03	2005
ibrandronic acid	5	mg	P	6	mg	P	M05BA06	2007
daclizumab	0.35	g	P	5	mg	P	L04AC01	2018
sirolimus	6	mg	O	3	mg	O	L04AA10	2006
amprenavir	2.4	g	O	1.2	g	O	J05AE05	2006
posaconazole	0.8	g	O	0.3	g	O	J02AC04	2017
colistin	3	MU	P	9	MU	P	J01XB01	2019
ciprofloxacin	0.5	g	P	0.8	g	P	J01MA02	2019
meropenem	2	g	P	3	g	P	J01DH02	2019
cefepime	2	g	P	4	g	P	J01DE01	2019
ceftezole	6	g	P	3	g	P	J01DB12	2008
amoxicillin and beta-lactamase inhibitor	1	g	O	1.5	g	O	J01CR02	2019
amoxicillin and enzyme inhibitor	1	g	P	3	g	P	J01CR02	2005
ampicillin and enzyme inhibitor	2	g ³⁾	P	6	g ³⁾	P	J01CR01	2017
temocillin	2	g	P	4	g	P	J01CA17	2019
amoxicillin	1	g	P	3	g	P	J01CA04	2019
amoxicillin	1	g	O	1.5	g	O	J01CA04	2019
ampicillin	2	g	P	6	g	P	J01CA01	2019
desmopressin	0.36	mg ¹⁾	SL	0.24	mg ¹⁾	SL	H01BA02	2009
vasopressin (argipressin)	4	U	P	40	U	P	H01BA01	2019
mifepristone	0.6	g	O	0.2	g	O	G03XB01	2017
human menopausal gonadotrophin	30	U	P	75	U	P	G03GA02	2016
atorvastatin	10	mg	O	20	mg	O	C10AA05	2009
fluvastatin	40	mg	O	60	mg	O	C10AA04	2009
pravastatin	20	mg	O	30	mg	O	C10AA03	2009
lovastatin	30	mg	O	45	mg	O	C10AA02	2009
simvastatin	15	mg	O	30	mg	O	C10AA01	2009
blood coagulation factors	1					deleted ²⁾	B02BD	2017
apixaban	5	mg	O	10	mg	O	B01AF02	2016
rivaroxaban	10	mg	O	20	mg	O	B01AF01	2016
dabigatran etexilate	0.22	g	O	0.3	g	O	B01AE07	2016
thioctic acid	0.2	g	O,P	0.6	g	O,P	A16AX01	2017
liraglutide	1.2	mg	P	1.5	mg	P	A10BJ02	2020
gliclazide	0.16	g	O	60	mg	O	A10BB09	2011
aprepitant	95	mg	O	165	mg	O	A04AD12	2019
aprepitant ⁵⁾	95	mg	P	150	mg	P	A04AD12	2019
alosetron	2	mg	O	1	mg	O	A03AE01	2005
glycopyrronium bromide	3	mg	P	0.3	mg	P	A03AB02	2018
esomeprazole	20	mg	O	30	mg	O	A02BC05	2005

1) Base.
2) DDDs for the various blood coagulation factors in all ATC 5th level codes in B02BD are deleted. No new DDDs will be established in B02BD Blood coagulation factors.
3) Refers to ampicillin.
4) The DDD for tiotropium bromide is unchanged but has been defined as the content of one inhalation capsule (18 mcg) as tiotropium. Since there are different inhalation capsules on the market containing different amounts of active substance, the DDD is now defined as the delivered dose, which is the same (10 mcg) as tiotropium for all products.
5) Refers to fosaprepitant

Last updated: 2022-04-07