Postal address:
WHO Collaborating Centre for Drug Statistics Methodology
Norwegian Institute of Public Health
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0213 Oslo

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Tel:  +47 21 07 81 60

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See also C03 - Diuretics, C07 - Beta blocking agents, C08 - Calcium channel blockers and C09 - Agents acting on the renin-angiotensin system.
Antihypertensives are mainly classified at 3rd levels according to the mechanism of action. Most headings are self-explanatory:
C02A Antiadrenergic agents, centrally acting
C02B Antiadrenergic agents, ganglion-blocking
C02C Antiadrenergic agents, peripherally acting
C02D Arteriolar smooth muscle, agents acting on
C02K Other antihypertensives
C02L Antihypertensives and diuretics in combination
C02N Combinations of antihypertensives in ATC gr. C02

The oral DDDs are based on the average doses needed to reduce the blood pressure to a normal level in patients with mild-moderate hypertension.
Parenteral DDDs are based on dosages used for the treatment of hypertensive crises and are based on the content of the active ingredient pr. vial (ampoule).


C02AA Rauwolfia alkaloids

This group comprises plain and combined rauwolfia preparations used in hypertension.
There are separate 5th levels for combinations of rauwolfia alkaloids (C02AA03) and for rauwolfia, whole root (C02AA04).
Combinations with beta blocking agents, see C07F - Beta blocking agents, other combinations.
Combinations with diuretics, see C02LA - Rauwolfia alkaloids and diuretics in combination.
Combinations with other antihypertensives, see C02N - Combinations of antihypertensives.
Combined products are otherwise classified at separate 5th levels using the corresponding 50-series.

C02AB Methyldopa

Combinations with diuretics, see C02LB - Methyldopa and diuretics in combination.
Combinations with Rauwolfia alkaloids and diuretics, see C02LA - Rauwolfia alkaloids and diuretics in combination.

Different DDDs have been established for the various stereoiso-meric forms of methyldopa, because of different potency.

C02AC Imidazoline receptor agonists

Clonidine and guanfacine also used in ADHD are classified in this group.
Low strength clonidine preparations used in the treatment of migraine are classified in N02C - Antimigraine preparations.
Combinations with diuretics, see C02LC - Imidazoline receptor agonists in combination with diuretics.

Last updated: 2021-12-14