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M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS

This group comprises antiinflammatory and antirheumatic preparations for systemic use.

The substances in this group have a broad range of indications, however, they should be kept together in M01A.

NSAIDs in combination with paracetamol are classified in N02BE.

Corticosteroids, see H02 - Corticosteroids for systemic use.

Disease Modifying Antirheumatic Drugs (DMARDs) see:
A07EC - Aminosalicylic acid and similar agents
L01BA - Folic acid analogues
L04AA - Selective immunosuppressants
L04AX - Other immunosuppressants
M01C - Specific antirheumatic agents
P01BA - Aminoquinolines

All preparations containing salicylic acid and derivatives are classified in N02BA - Salicylic acid and derivatives, as it is difficult to differentiate between use of salicylates in rheumatic conditions and other therapeutic uses.

Exception: Salicylates in combination with corticosteroids are classified in M01B.

Combinations of antiinflammatory/antirheumatic agents (e.g. corticosteroids) are classified in M01B.

Combinations with muscle relaxants are classified in M03B.

Combinations with antibacterials are classified in J01.

Antiinflammatory or antirheumatic agents in combination with opioids are classified in N02AJ - Opioids in combination with non-opioid analgesics.


Combined cold preparations with therapeutic levels of antiinflammatory agents are classified in this group at separate 5th levels by using the 50-series.

Combinations with drugs classified in A02B (e.g. esomeprazole) are classified in M01A using the 50-series.

The DDDs are based on the treatment of rheumatoid arthritis, except for the coxibs (M01AH).


M01AA Butylpyrazolidines
M01AB Acetic acid derivatives and related substances
M01AC Oxicams

Piroxicam and piroxicam-beta-cyclodextrin are given the same ATC 5th level code M01AC01.

The DDD for meloxicam is based on the treatment of osteoarthritis.

M01AE Propionic acid derivatives

All plain ibuprofen preparations are classified in this group, even if they are only intended for use as pain relief.

Combinations of ibuprofen and paracetamol are classified in N02BE51.

Ketoprofen lysine is classified at the same ATC 5th level as ketoprofen.

Ibuprofen lysine is classified at the same 5th level as ibuprofen.

M01AG Fenamates

Tolfenamic acid, used in the treatment of migraine, is classified here.

M01AH Coxibs

Celecoxib used in FAP (familiar adenomatous polyposis) is classified in L01XX.

The DDDs for the coxibs are based on the treatment of osteoarthritis.

M01AX Other antiinflammatory and antirheumatic agents, non-steroids

This group comprises antiinflammatory and antirheumatic drugs which cannot be classified in the preceding groups.

The DDD for glucosamine refers to glucosamine sulfate.

Last updated: 2018-12-13